AR-V7 Expression Predicts Prostate Cancer Outcomes

Radical prostatectomy (RP) specimens with unfavorable pathol‐ ogy increased over nine years, but the reasons remain unclear, according to a study reported at the American Urological Asso‐ cia on (AUA) 2016 Annual Mee ng. Results were reported by Katherine Rotker, MD, of Brown University in Providence, RI. Following US Preven ve Health Services Task Force (USPSTF) 2009 and 2012 recommenda ons against PSA screening, the rate of RPs declined but the age of men undergoing RP did not change. There was a shi towards more Gleason 8‐10 disease, and the frequency of organ‐confined disease decreased. Rotker reported findings from a comparison of pathologic find‐ ings at RPs performed at Brown during three me periods. The first group represented men who had RP from 2006 to 2008 (before USPSTF recommended against PSA tes ng in men ≥75). The second group captured the RP experience from 2009 to May 2012 (before USPSTF recommended against rou ne screening for men of any age). The third group represented the pathological findings at RP from May 2012 to May 2015 (following the 2012 USPSTF recommenda on). Rotker reported that: The number of RPs decreased from 561 in group 1 to 476 (15%) in group 2 to 311 (35%) in group 3 Mean age of men undergoing RP remained stable at 60 through the study period The propor on of specimens with pure Gleason grade 6 de‐ creased from 46% to 24% (P<0.001) to 12% (P <0.001)